A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

نویسندگان

  • S C Barr
  • K L Warner
  • B G Kornreic
  • J Piscitelli
  • A Wolfe
  • L Benet
  • J H McKerrow
چکیده

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 49 12  شماره 

صفحات  -

تاریخ انتشار 2005